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So cycling MOTS-c is prudent practice rather than a pharmacologic requirement

Apoptosis and the response to anticancer therapy

(2) Oxidative stress modulation: Upregulates the nuclear factor erythroid 2-related factor 2 (NRF-2), heme oxygenase 1 (HO-1), and glutathione-S-transferase- (GST-) antioxidant axis while downregulating toll-like receptor-2 (TLR-2), myeloid differentiation protein-88 (MYD-88) levels, thereby reducing IL-1, TNF-, and IL-8 expression in HFD-fed tilapia ( Oreochromis niloticus ) [144]