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Dose escalation in the phase 3 trial is designed to reduce the incidence of gastrointestinal adverse events when switching to monthly dosing
Vascular running is the process by which vessels grow toward an area of injury or around an area of vascular occlusion to reestablish blood flow to distal tissue and protect cell function [9]
This procedure involved removing the supernatant and resuspending the mitochondrial pellet in an isolation buffer of 250 mM sucrose, 0.5 mM EDTA, and 10 mM Tris-HCl to achieve a final protein concentration of 20-25 mg/ml [2]
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