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Protective effect of depot-medroxyprogesterone acetate on surgically treated uterine leiomyomas: a multicentre casecontrol study

10.1016/j.cell.2011.10.026 72 MonieriM.RainoneP.SacchiA.GoriA.GasparriA

Major PK Uncertainties: Translational Scaling : The PK parameters (especially clearance rates and effective doses) observed in small animals do not reliably scale up to humans