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Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction
Topical penetration is better than many assume
AOD-9604 may have a role as an adjunct in a broader, supervised protocol, but it should not be presented as a primary fat-loss therapy
Cosmetic-grade copper tripeptide-1 is a formulated topical product subject to cosmetic regulation, with no comparable analytical disclosure
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