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They include excess abdominal weight, high blood pressure, high blood sugar levels and high cholesterol
PMID 15670850
In contrast, high glucose levels primarily trigger insulin secretion, which is amplified by GLP-1 receptor stimulation in GLP-1R-MIN-6 cells
(Peptide Sciences) While senescence is protective in acute contexts (e.g., preventing malignant transformation, wound repair), the accumulation of senescent cells over time is detrimental: They occupy tissue space and resources, impairing progenitor cell function
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