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Stimulation of TGF-1 production in cultured mouse renal tubular cells after complement activation by C3a and C5a binding to C5a receptor and C3a receptor, and stimulation of proximal tubular epithelial cells by MAC leading to increased expression of type IV collagen mediate renal fibrosis resulting in the transition from AKI to CKD [26]
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The subjective effects of psychedelics may not be necessary for their enduring therapeutic effects
AUTHORS Joseph Lee is a General Practitioner and doctoral researcher based at the Nuffield Department of Primary Care Health Sciences, University of Oxford
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