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A negative feedback transcription cycle is eventually formed to maintain the oscillation of the gene expression ( REV-ERB , retinoic acid-borne orphaned binders a ( ROR ), DEC1 , DEC2 , and albumin D-binding ( DBP ), which form an auxiliary loop that stabilizes the main regulatory loop (Takahashi et al., 2008
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This happens through its ability to inhibit melanin production, which can gradually reduce pigmentation, tanning, and uneven skin tone
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