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GLP-1 medications solve this by using modified versions of the hormone that resist enzymatic breakdown, maintaining elevated levels for days or even a full week depending on the formulation

FEBS J 281(8):20882096 Linnebank M, Moskau S, Semmler A, Widman G, StoffelWagner B, Weller M et al (2011) Antiepileptic drugs interact with folate and vitamin B12 serum levels

Regulation of hepatic glutathione synthesis: Current concepts and controversies

[37] [38] The use of the Bergmann-Zervas method remained the standard practice in peptide chemistry for two full decades after its publication, superseded by newer methods (such as the Boc protecting group) in the early 1950s