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Notably, astrocyte loss of functions can lead to elaboration of potentially toxic molecules such as ROS or certain lipids and this may be mistaken for a purposeful gain of detrimental function
Mutations of ADNP and SHANK3 impair the binding of ADNP and Shank3 to actin leading to autistic behaviors, anxiety, and depression due to synaptic dysfunctions [283, 293]
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