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A new generation of pharmacotherapies have been developed which combine GLP-1R agonism with other metabolic hormones into a single molecule

In this work we directly compare the prototypical GLP-1RA exendin-4 with its C-terminally acylated analogue, exendin-4-C16, for their relative propensities to recruit and activate G proteins and -arrestins, endocytic and post-endocytic trafficking profiles, and interactions with model and cellular membranes

This centralization helps the court coordinate expert discovery, pretrial motions, and depositions across thousands of related cases

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