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Most patients notice initial appetite reduction within the first 1-2 weeks of starting oral tirzepatide, though measurable weight loss typically becomes apparent after 4-6 weeks of consistent use
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Energy restriction requires coordinated metabolic reorganization involving hepatic glucose output, adipose tissue lipolysis, skeletal muscle protein turnover, and mitochondrial fuel selection
The biology of incretin hormones, Reprinted from Cell Metabolism, 2006
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