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This treatment is not appropriate for individuals with active infections, immunocompromised states, or contraindications determined by clinical evaluation

Similarly, the current American Urological Association and American Society for Reproductive Medicine guidelines question the benefits of AOXs in treating male infertility, and indicate lack of data to recommend the use of specific agents for this purpose (Moderate Recommendation

Limited Clinical Safety Data : The human safety profile remains unclear because the evidence is primarily based on animal and laboratory studies rather than large-scale clinical trials