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One mechanism of dioxin-induced liver toxicity is the activation of the AhR in the hepatocytes, which results in a continuous production of higher levels of ROS and a significant increase in lipid droplets in the liver, producing a similar change observed in NAFLD (Furue et al

In the UK, the Medicines and Healthcare products Regulatory Agency (MHRA) has licensed these medications for specific uses, usually involving the management of type 2 diabetes or as a support for weight loss in individuals with a high BMI and weight-related health complications

Importantly, PDGF signalling bypasses IRS and thus provides a tool to test the role of IRS in insulin resistance