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When ER stress is excessive or prolonged beyond the adaptive threshold, UPR signaling can shift from cytoprotective to pro-apoptotic outcomes, frequently through crosstalk with mitochondrial death pathways

PRECAUTIONS: Consult a healthcare professional before use, particularly if pregnant, breastfeeding, or taking medications/supplements, or if you have a medical condition

This response, known as post-inflammatory hyperpigmentation (PIH), occurs when melanin production ramps up around the injured area

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