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B6 is vital for immune functions and serves as a biomarker of inflammation, with its down-regulation associated with severe inflammation
The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison
For deficiency, B12 shots are given weekly or every other week at first
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