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It is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) first created to treat type 2 diabetes

The MHRA stressed that healthcare professionals should identify the increased risk of aspiration as early as possible before surgery and specifically at pre-assessment clinic before surgery, and remind patients to inform their healthcare teams and anaesthetists if they are on GLP-1 or dual GIP/GLP-1 RAs

Data from the STEP and SUSTAIN clinical trial programmes have shown that weight loss with semaglutide includes some reduction in lean body mass alongside fat mass, which could potentially contribute to muscle symptoms

Over-the-counter products marketed as a lip dark spot remover may slightly lighten surface discoloration, but they rarely eliminate true sun spots, freckles, or smoking-related pigmentation