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All of the procedures were carried out under the supervision of the committee and the animal laboratory principles
There is a question if a nutrient with antioxidant activity can cause the opposite effect with pro-oxidant activity if too much is taken
Disulfiram acts by inducing nausea upon alcohol consumption, naltrexone is a mu-opioid receptor antagonist, therefore having broad action on the reward system, and the action of acamprosate is less well understood, but it is likely an allosteric modulator of GABAa receptors
It works well on its own and is the simpler of the two options
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