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And so, DNA with single- and double-strand breaks released that lead to bacterial death 6

Diabetes increases expression of pro-apoptotic Bax and phosphorylation of JNK, while suppressing anti-apoptotic Bcl-2, thus promoting cell death of germ cells, Sertoli cells, and Leydig cells [241]

By mediating the transcription of crucial antioxidative enzymes, FOXO4 may help mitigate oxidative stress and maintain cellular integrity and function during episodes of high oxidative load or inflammation