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Cognetta AB Jr et al (2001) Dermatoscopy of lentigo maligna
Research suggests that the mechanism involves: Chronic UV damage to melanocytes in localized areas Reduction in melanocyte number or melanocyte function in affected spots Decreased melanin production leading to visible white patches Skin aging processes that compound the pigment loss[2] The exact trigger that causes melanocytes to fail in specific spots while leaving surrounding skin unaffected remains partially mysterious, hence the "idiopathic" designation[7]
Fortunately, glutathione can provide some answers
The drug is also just launching supply and availability are uncertain in early 2026
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