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For example, the tumor-inhibitory functions of inflammasomes containing NLRP6, one of the most abundantly expressed PRRs in the colon, include maintaining epithelial barrier integrity through intestinal epithelium self-renewal
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The human record: one PK study and one failed trial The dose-escalation study in healthy male volunteers used five 15-minute IV infusion rates (4.21 to 140.45 nmol/kg), eight men per level
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