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Moreover, astrocyte-derived neurotrophic factors are considered valuable targets for AD and ischemic stroke, as they stimulate astrocyte-mediated neurogenesis and angiogenesis or enhance their neuroprotective profiles through growth factors and antioxidants 124,127

Imidazoline (I Clonidine is an imidazoline derivative that binds to central imidazoline I 1 ) Receptor Agonism: 1 receptors in the brainstem (including the nucleus tractus solitarii and rostral ventrolateral medulla) with high affinity