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Furthermore, NOX2 activity was downregulated in peripheral neutrophils of ALS patients, which also correlated with improved survival and disease outcomes (Marrali et al., 2014)
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If diarrhoea develops, Dulcolax should be discontinued, as excessive bowel stimulation can lead to dehydration and electrolyte disturbances
Patients who might be considered for GLP-1 therapy (within licensed indications) and who may experience secondary benefits for binge eating behaviours include: Individuals with binge eating disorder and type 2 diabetes , where GLP-1 agonists address the primary diabetes indication whilst potentially helping with eating patterns Those with BED and obesity who meet NHS eligibility criteria for weight management medications (as defined by NICE TA875 for semaglutide or TA664 for liraglutide, which are narrower than the marketing authorisation) Patients who have not responded adequately to psychological interventions such as cognitive behavioural therapy (CBT) and who have concurrent metabolic conditions Those experiencing significant food cravings and loss-of-control eating as part of their weight management challenges However, important cautions and considerations apply
