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Nuclear -catenin upregulates ZEB1, a key EMT transcription factor, which enhances invasiveness and suppresses DNA repair, thereby reducing chemosensitivity to agents such as doxorubicin
It is more of a short-duration ceiling
Detoxamin is designed to remove toxic metals but may also remove some essential elements, therefor a good vitamin/mineral supplement must be taken during treatment
GHKCu limits this by reducing pro-inflammatory cytokines (e.g., IL-6, TNF-) and promoting antioxidant defenses
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