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Understanding this mechanism clarifies why GLP-1-based therapies have become central to modern diabetes and obesity management

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Semaglutide works by acting like a natural gut hormone that helps the body release insulin when blood sugar is high, reduces the amount of sugar made by the liver, and slows stomach emptying

By covalent (albiglutide, dulaglutide) or no-covalent (semaglutide) coupling to larger molecules with slow clearance, analogs with even more prolonged activity have been produced so that there are now several once-weekly agonists on the market