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Clinical context matters

In Wales the All Wales Medicines Strategy Group (AWMSG) and in Northern Ireland -the Department of Health, Social Services and Public Safety (DHSSPS) decide how they will be implemented locally

Standard dosing Daily dose: 300-600mcg per day Injection frequency: Once daily, preferably in the morning on an empty stomach Administration route: Subcutaneous injection Most users start at 300mcg to assess tolerance, then increase to 500-600mcg if the lower dose is well-tolerated but results are modest

NNMT is expressed abundantly in adipose tissue, where it has been associated with fat cell size and lipid storage dynamics