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So the weight gain reflects a biological shift, which is why the same diet and exercise that worked before often stop working and a different strategy is needed
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as of May 2026
GLP-1 Receptor Agonists, Obesity, and Cardiovascular Disease Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were originally developed to improve glycemic control in type 2 diabetes but have since demonstrated benefits in weight reduction and cardiovascular risk modification, including in people without diabetes
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