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Reading Across From GLP-1 Receptor Agonists in PCOS If retatrutide itself has never been studied in PCOS, the closest available analog is the GLP-1 receptor agonist class liraglutide, semaglutide, exenatide, and dulaglutide which shares retatrutides central appetite-suppressing, incretin-based mechanism (retatrutide simply adds GIP and glucagon arms on top)
Obesity affects roughly 42% of U.S
2016 Mar 1;148:63-70
TRIUMPH-1's 11.3% represents an improvement over TRIUMPH-4's 18.2%, and suggests the general obesity population tolerates retatrutide better than the older, more comorbid OA population in TRIUMPH-4
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