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This is one of the more mechanistically grounded areas of glutathione research, and why hepatic applications come up often in clinical discussions

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Annu Rev Biochem 52:711760 Njalsson R, Norgren S, Larsson A, Huang CS, Anderson ME, Luo JL (2001) Cooperative binding of gamma-glutamyl substrate to human glutathione synthetase

This observation suggests that selenium may influence HA release, at least in part, regardless of the oxidative stress induced by H 2 O 2 , through mechanisms that are still to be clarified