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New GLP-1RAs and combinations, including oral options and multi-agonists like retatrutide and maritide, show promise
Some effects occur within minutes, such as blood glucose and insulin concentrations, while others, such as effects on synaptic density, muscle mass, or bone density, may take months
Exenatide (Byetta , Bydureon ) Exenatide was the first GLP-1 approved for clinical use
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