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By persistently reducing nutrient inflow while maintaining or redistributing oxidative demand, GLP-1RA therapy establishes a state of chronic energy flux constriction
Probucol, a lipid-lowering agent, also exhibits antioxidant properties that reduce intracellular oxidative stress and maintain normal cellular redox state by upregulating Nrf2 and GPX4 protein expression, thereby enhancing cardiomyocyte antioxidant capacity
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