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Its small molecular weight (~400 Da) supports transdermal penetration through scalp skin
A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient
The depth of skin that is removed is extremely thin
Typical review language: "By day 3 I could actually get through my afternoon without crashing," "First time in months I didn't need a 2 PM coffee," "The brain fog lifted completely." 2
