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[2][8] When vomiting is a concern: Dehydration repeated vomiting prevents adequate fluid intake, which can become medically significant Electrolyte imbalance loss of fluids and stomach acid disrupts sodium, potassium, and chloride levels Inability to take other medications vomiting can prevent absorption of other essential drugs Pancreatitis (rare) severe abdominal pain accompanied by vomiting may indicate pancreatic inflammation, a rare but serious adverse event [6][8] Bowel obstruction (rare) extremely slowed gut motility in susceptible individuals can, in rare cases, progress to obstruction [2] The Mayo Clinics tirzepatide prescribing information flags severe abdominal pain, persistent vomiting, and signs of dehydration as reasons to seek immediate medical attention

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