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The advantage of our measurement of the Glutathione Index (GSH/GSSG) is therefore that it shows changes in GR activity not only due to higher/lower GR gene activity but also due to the absence of the reaction cofactor NADP

Diabetologia 53 (3), 552561

The molecule was designed so that all three receptor activities are present at meaningful but balanced potencies: too much glucagon-receptor activation would raise hepatic glucose output and undo the glycaemic benefit, whereas too little would lose the energy-expenditure arm that motivates including glucagon in the first place

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