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Amino Acids 32(3):333340 Segel GB, Woodlock TJ, Murant FG, Lichtman MA (1989) Photoinhibition of 2-amino-2-carboxybicyclo [2,2,1]heptane transport by O-diazoacetyl-l-serine

Obesity rates have almost tripled since 1975, which researchers say is due to a combination of factors, including: Increased access to energy-dense food coupled with reduced physical activity Sleep deprivation Circadian desynchronization Chronic stress A rise in the use of certain medications known to result in weight gain, including some anti-epileptic and psychotropic drugs Other genetic and environmental factors As a result, prescription drug companies have sought their own way to target the treatment of obesity

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One consequence of this is impairment of the urea cycle, exacerbating hyperammonemia