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Discuss at your next appointment if: you have reached week 8 with zero noticeable appetite or weight changes at your current dose, side effects are manageable but annoying and not improving, you are considering adjusting your dose escalation timeline, you want to explore combination approaches, or you are experiencing insomnia , menstrual changes , feeling unusually cold , or hormonal changes that you suspect are related to the medication

The skull radiographs revealed a soft tissue swelling with sclerosis of the underlying frontal bone along the midline

Bottom line, Gerstein said, there are no official guidelines for microdosing these drugs and no solid data on how safe it is or what the effects might be, good or bad