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44 Unfortunately, due to the delay of onset from surgery to deficiency, case reports suggest that by the time the patient presents with symptoms, they are typically severely depleted
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In animal studies, hydroxocobalamin administered to pregnant rats and rabbits during the period of organogenesis caused skeletal and soft tissue abnormalities, including alterations in the central nervous system, at exposures similar to human exposures at the therapeutic dose (see Data )
The lack of preservative means bacterial growth becomes a concern quickly
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