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Low HRV is associated with increased sympathetic (fight/flight) nervous system (SNS) activity, and/or decreased parasympathetic (rest/digest) nervous system (PNS) activity, and is associated with chronic inflammatory disease, cardiovascular disease, stroke, diabetes, irritable bowel syndrome, interstitial cystitis, chronic pain, and ME/CFS and FM

Accompanying the inward movement of GIPR ECL1 by 6.4 relative to that of GCGR (measured by C of G202 ECL1 in GIPR and G207 ECL1 in GCGR), the C terminus of peptide 20 bound by GIPR shifted toward the TMD core by 8.1 (measured by C of L27 P ) and consequently pushed the extracellular tip of TM1 towards TM7 by 2.8 (measured by C of the residues at 1.29b)

Elle pourrait aussi jouer un rle au niveau du cur, du foie, des muscles et du cerveau