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Despite these limitations, phenotype-based treatment holds substantial potential for improving patient outcomes by increasing treatment efficacy, sustainability of weight loss, and optimized use of pharmacotherapy

While carnitine is generally safe, some research suggests it may be pro-atherogenic, but additional long-term trials assessing its effects on the cardiovascular system are necessary.

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Ensuring equitable access to these effective but high-cost medications, as well as supporting individuals so that they can stay on the therapy long-term, should be a priority for our clinicians and policymakers. The findings, which were presented at the American Heart Association Scientific Sessions and simultaneously published in JAMA Cardiology, underscore the need to increase equitable access to this new class of pharmaceuticals