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With an oral supplement, the B12 needs to be absorbed through your digestive system first before getting to your blood, which takes a lot longer

Unlike fat-soluble vitamins (A, D, E, and K), which are stored in fat tissue for long periods, water-soluble vitamins are processed relatively quickly: your body takes what it needs, stores a small amount in the liver, and passes most of the rest in urine

For background on how to interpret peptide research literature, see our peptide glossary, which defines terms such as EC50, receptor affinity, and bioavailability

( 11 ) However, if youre severely deficient in Vitamin B12, it may take several weeks to fully restore your levels and feel the cumulative benefits