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Indeed, MDA-MB-231 breast cancer cells and non-malignant retinal pigment epithelium cells (hTERT RPE-1) as well as human foreskin fibroblasts (HFF) also showed a significant increase in cell area and FA number upon aldolase depletion but not upon PFK or GAPDH loss, demonstrating that the differential impact of glycolytic enzymes on adhesions is conserved across cell types (Extended Data Fig

In general, three phases of metabolic detoxification of xenobiotics have been often described in the literature

Monitor for diminishing effects, which may indicate the need for reduced frequency or a complete break from DSIP