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Although comparisons of abundance between different tryptic peptides are not feasible due to differences in ionization efficiencies of each peptide, these results confirm that glutathionylation of each cysteine in WT GLRX occurs following incubation with GSSG, and suggest that C23, C26, and C8 are more readily glutathionylated at lower concentrations of GSSG

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The low-frequency non-synonymous A316T (rs10305492) variation in the GLP1R coding sequence is associated with lower fasting glucose levels and reduced risk of type 2 diabetes, but it is accompanied by a weakened insulin response to glucose challenge, reduced insulinogenic index, and increased 2-hour postprandial glucose levels