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The AD-associated APOE4 allele has been reported to enhance lactate synthesis, thereby altering the metabolic milieu, and to sensitize astrocytes to inflammatory stimuli without overtly changing baseline transcriptomic profiles
It is no coincidence, then, that the share of Americans using weight-loss drugs more than doubled between early 2024 and summer 2025, from 5.8% to 12.4%
C., Porte, D
Begin with a comprehensive thyroid workup, optimize hormone therapy, and introduce GLP-1s gradually if appropriate.
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