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Key quantitative findings included dose-dependent increases in CXXC5 expression following PGD2 treatment, corresponding decreases in beta-catenin and PCNA (a proliferation marker), restoration of Wnt signaling and cellular proliferation with PTD-DBM treatment, and complete resistance to PGD2-induced hair loss in CXXC5 knockout mice

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Regulation of the Pentose Phosphate Pathway The major regulator of the PPP is the cellular response to oxidative stress

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