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doi: 10.3390/nu12010157

Most studies concerning the effects of IGF-1 derivatives have been carried out in non-human animal models or cell culture studies Insulin Like Growth Factor Receptor Interactions IGF-1 binds to at least two cell surface receptors: IGF-1R and the insulin receptor

Metabolic dysfunction involves substantial inflammatory components adipose tissue inflammation, systemic inflammatory markers, and inflammation-mediated insulin resistance are all documented research targets

The American Diabetes Association (ADA) recognizes the cardiovascular benefits of GLP-1 receptor agonists in their Standards of Care but does not currently recommend these agents solely for inflammation management outside established indications for diabetes, obesity, or cardiovascular risk reduction