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TRIUMPH-3: Obesity with Established Cardiovascular Disease (July 2026) TRIUMPH-3 enrolled 1,949 adults with severe obesity (BMI 35) and established cardiovascular disease, with or without type 2 diabetes, randomized 1:1:2 to retatrutide 9mg, 12mg, or placebo over 80 weeks
Importantly, when patients stop semaglutide, the weight they regain tends to be mostly fat mass not lean mass, leaving them potentially worse off in terms of joint support and musculoskeletal health
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Individuals with a history of thyroid conditions or MTC should discuss the potential risks with their healthcare provider
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