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Unraveling the complex relationship between folate and cancer risk

This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Dias et al., 2013)

Studies show that under conditions of low GPX4 expression, DHODH effectively suppresses mitochondrial lipid peroxidation and ferroptosis

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