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Important safety considerations include: avoid use if you have aspirin allergy, are taking anticoagulants or other salicylate medications, have bleeding disorders, or kidney disease
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These trials, including STEP-1 through STEP-6, highlighted semaglutides superiority over placebo and other treatments, such as liraglutide, in promoting weight loss and enhancing cardiometabolic parameters, including blood pressure and lipid profiles [6][15]
In short: TRIUMPH-3 shows retatrutide can be used safely in a cardiovascular disease population without signal of harm, but the question of whether it actively reduces heart attacks and strokes remains open until TRIUMPH-Outcomes reports
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