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It carries an FDA black box warning for a risk of thyroid C-cell tumors, based on animal studies [5]
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The pharmacovigilance data shows slightly different reporting odds ratios for alopecia across GLP-1 receptor agonists: Tirzepatide: ROR of 1.73 (95% CI: 1.42-2.09) Semaglutide: ROR of 1.42 (95% CI: 1.3-1.55) Liraglutide: Lower reporting rates, but also less dramatic weight loss The pattern is telling
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