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Oral alternatives must be ineffective, contraindicated, or unavailable

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Glucocorticoids can suppress glycolysis by blocking the transcriptional and post-translational effects of hypoxia-inducible factor 1 (HIF-1) in macrophages, while promoting glutamine metabolism to enhance TCA cycle flux and succinate metabolism, thereby preventing intracellular succinate accumulation and facilitating the conversion of macrophages from the M1 to the M2 phenotype (112, 113)

TGFBI promotes tumor growth and is associated with poor prognosis in oral squamous cell carcinoma