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Given the risk of serotonin syndrome when methylene blue is used concomitantly with serotonergic drugs, it is crucial to monitor for symptoms such as mental status changes (e.g., agitation, hallucinations), autonomic instability (e.g., tachycardia, labile blood pressure), neuromuscular symptoms (e.g., tremor, rigidity), and gastrointestinal symptoms (e.g., nausea, diarrhea)

Most people take 1 tablet or capsule per day

Most people report minimal pain with subcutaneous injections

Acid-reducing medications such as proton pump inhibitors (PPIs) like omeprazole or H2 blockers like famotidine may benefit patients who experience nausea accompanied by acid reflux or heartburn